Autoimmune bullous skin diseases, pemphigus and pemphigoid

The immunopathology of pemphigus and bullous pemphigoid.

This review article was prepared for the Journal of Investigative Dermatology by invitation. It is the first of a series of such articles which will appear in this journal in the months to come. Doctor Richard Winkelmann has taken on the responsibilities of obtaining and organizing these reviews. The Society for Investigative Dermatology is deeply grateful for his efforts and is particularly in...

New Observations in Autoimmune Bullous Skin Diseases

Bullous Skin Diseases: Classical Types of Autoimmune Diseases

The prototypic bullous skin diseases, pemphigus vulgaris, pemphigus foliaceus, and bullous pemphigoid, are characterized by the blister formation in the skin and/or oral mucosa in combination with circulating and deposited autoantibodies reactive with (hemi)desmosomes. Koch's postulates, adapted for autoimmune diseases, were applied on these skin diseases. It appears that all adapted Koch's pos...

Oral lesions in patients with pemphigus vulgaris and bullous pemphigoid.

Thirty three patients admitted to the University Department of Dermatology and Venereology, Sestre milosrdnice University Hospital, were included in the study. The purpose of the study was to compare data on age and gender, habits, lesion localization, onset of symptoms and therapy between patients with pemphigus vulgaris and those suffering from bullous pemphigoid. Based on clinical presentati...

Serum protein carbonyl and total antioxidant capacity levels in pemphigus vulgaris and bullous pemphigoid

Background: Pemphigus diseases including pemphigus vulgaris (PV) and bullous pemphigoid (BP) are autoimmune diseases that cause severe blistering of the skin and mucous membranes. Among inflammatory mediators, reactive oxygen species (ROS) are involved in the pathogenesis of a wide variety of diseases through oxidative stress for which protein carbonyl (PC) and total antioxidant capacity (TAC) ...